The UK and Israel have vowed to 'work night and day' to stop from ever becoming a nuclear power.
Liz Truss and her counterpart, Yair Lapid, are set to agree a new decade-long plan to boost cooperation and strengthen ties between the two countries.
They are due to meet in today to sign a 'memorandum of understanding' aimed at stronger collaboration on issues such as cybersecurity, defence and trade.
The deal will make Israel one of the UK's closest partners on cyber security while talks on a new trade deal are expected to start next year.
Perhaps the most significant commitment being made by the two countries under the new pact is to do more to thwart Iran's nuclear ambitions.
In a joint article for The Telegraph, Ms Truss and Mr Lapid said: 'We will work night and day to prevent the Iranian regime from ever becoming a nuclear power.'
The Iran nuclear deal, first agreed in 2015, saw Tehran agree to stop its pursuit of nuclear weapons in exchange for economic sanctions being lifted.
The deal suffered a hammer blow when then-US president Donald Trump withdrew from it and reimposed sanctions, prompting Iran to restart its nuclear programme.
Efforts to get the deal back in place are ongoing, with indirect talks due to resume in Vienna this week, but a breakthrough appears to be some way off.
Ms Truss and Mr Lapid described the new 10-year plan between the UK and Israel as a 'major step forward'.
They wrote: 'Israel and the UK are the closest of friends, and today we are deepening that partnership to become even closer.
'This pact will spur technological breakthroughs which have the potential to change the world, create high-quality jobs in both our countries and provide tools to our security forces.'
Ms Truss and Mr Lapid also signalled negotiations will soon begin on a bespoke free trade agreement between the UK and Israel.
They said 'our great nations can do so much more to create jobs and fuel economic growth' and 'that is why we will pave the way to negotiating a bespoke UK-Israel free trade agreement'.
On the issue of cyber security, they said: 'With the world increasingly threatened in cyberspace, we will work together to defend ourselves.
'Israel will officially become a tier-one cyber partner for the UK, recognising how much more we can achieve together as tech leaders with world class cybersecurity expertise.'